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Purdue University
Dept. of Animal Sciences
915 W. State St.
West Lafayette, IN 47907-2054
Phone (765) 494-4808
Fax (765) 494-9346

Alan L. Grant, Ph.D.
Alan L. Grant

Department Head and Professor

Growth and Development

 

Research Interests


 

Skeletal Muscle Growth and Development

Objectives of the research program include characterization of the function and expression of growth factors involved in signaling pathways that influence skeletal muscle development. Much of our effort has been directed towards developing in vivo models to study these pathways. Much of the research is being designed to determine how muscle development is related to meat quality, and will contribute to strategies for increasing the efficiency food production and utilization.

Research Publications:

  1. Refereed Papers:

    2.

    1. Nocek, J.E. and A.L. Grant. 1987. Characterization of in situ nitrogen and fiber digestion and bacterial nitrogen contamination of haycrop forages preserved at different dry matters. J. Anim. Sci. 64:552-564.

    2. Blaze, C.A., R.E. Holland, and A.L. Grant. 1988. Gas exchange during xylazine-ketamine anesthesia in neonatal calves. Vet. Surgery 17:155-159.

    3. Grant, A.L., R.E. Holland, J.W. Thomas, K.J. King, and J.S. Liesman. 1989. Effects of dietary amines on the small intestine of calves fed soybean protein. J. Nutr. 119:1034-1041 (M.S. thesis research).

    4. Grant, A.L., J.W. Thomas, K.J. King, and J.S. Liesman. 1990. Effects of dietary amines on small intestinal variables in neonatal pigs fed soy protein isolate. J. Anim. Sci. 68:363-371 (M.S. thesis research).

    5. Grant, A.L., W.G. Helferich, R.A. Merkel, and W.G. Bergen. 1990. Effects of phenethanolamines and propranolol on the proliferation of cultured chick breast muscle satellite cells. J. Anim. Sci. 68:652-658 (Ph.D. research).

    6. King, K.J., J.T. Huber, M.S. Sadik, W.G. Bergen, A.L. Grant, and V.L. King. 1990. Influence of dietary protein sources on the amino acid profiles available for digestion and metabolism in lactating cows. J. Dairy Sci. 73:3208-3216.

    7. Bergen, W.G., T.M. Byrem, and A.L. Grant. 1991. Ensiling characteristics of whole-crop small grain harvested at milk and dough stages. J. Anim. Sci. 69:1766-1774.

    8. Grant, A.L., W.G. Helferich, S.A. Kramer, R.A. Merkel, and W.G. Bergen. 1991. Administration of growth hormone to pigs alters the relative amount of insulin-like growth factor-I mRNA in liver and skeletal muscle. J. Endocrinol. 130:331-338 (Ph.D. thesis research).

    9. King, K.J., V.L. King, A.L. Grant, B.D. Grieve, and W.G. Bergen. 1991. An assessment of absorbable lysine in lactating cows. J. Dairy Sci. 74:2530-2539.

    10. Griffin, M.E., P.B. Brown, and A.L. Grant. 1992. The dietary lysine requirement of juvenile hybrid striped bass. J. Nutr. 122:1332-1337.

    11. Skjaerlund, D.M., A.L. Grant, W.G. Helferich, W.G. Bergen, and R.A. Merkel. 1993. Determination of the relative abundance of skeletal muscle alpha actin mRNA in muscle of livestock species. J. Anim. Sci. 71:393-399.

    12. Steinmetz, R.W., A.L. Grant, and P.V. Malven. 1993. Transcription of prolactin gene in milk secretory cells of the rat mammary gland. J. Endocrinol. 136:271-276.

    13. Kramer, S.A., W.G. Bergen, A.L. Grant, and R.A. Merkel. 1993. Fatty acid profiles, lipogenesis, and lipolysis in lipid depots in finishing pigs treated with recombinant porcine somatotropin. J. Anim. Sci. 71:2066-2072.

    14. Grant, A.L., D.M. Skjaerlund, W.G. Helferich, D.B. Anderson, W.G. Bergen, and R.A. Merkel. 1993. Skeletal muscle growth and expression of skeletal muscle alpha actin mRNA and insulin-like growth factor-I mRNA in pigs during feeding and withdrawal of ractopamine. J. Anim. Sci. 71:3319-3326.

    15. Liu, C.Y., A.L. Grant, K.H. Kim, and S.E. Mills. 1994. Porcine somatotropin decreases acetyl-CoA carboxylase gene expression in porcine adipose tissue. Dom. Anim. Endocrinology 11:125-132.

    16. Liu, C.Y., A.L. Grant, K.H. Kim, S.Q. Ji, D.L. Hancock, D.B. Anderson, and S.E. Mills. 1994. Limitations of ractopamine to affect adipose tissue metabolism in swine. J. Anim. Sci. 72:62-67.

    17. Chang, C.H., A.L. Grant, G.M. Strasburg, W.G. Bergen, R.A. Merkel, and W.G. Helferich. 1994. RNA transcription in porcine skeletal muscle nuclei during postnatal development. Proc. Soc. Exp. Biol. Med. 206:162-168.

    18. Demos, B.P., J.C. Forrest, A.L. Grant, M.D. Judge, and L.F. Chen. 1994. Simulating sensory and physical properties of beef in low-fat, low-sodium restructured steaks. J. Muscle Foods 5:407-418.

    19. Gerrard, D.E. and A.L. Grant. 1994. Insulin-like growth factor-II expression in developing skeletal muscle of double muscled and normal cattle. Dom. Anim. Endocrinology 11:339-347.

    20. Gerrard, D.E., A.L. Grant, D.B. Anderson, R.P. Lemenager, and M.D. Judge. 1995. In-vivo analysis of serum-borne growth factors in developing co-twinned fetuses. J. Anim. Sci. 73:1689-1693.

    21. Briley, G.P., J.M. Reecy, A.L. Grant, and C.A. Bidwell. 1995. Cloning and expression of the porcine myogenin gene. Anim. Biotech. 6:79-92.

    22. Schinckel, A.P., L.K. Clark, G. Stevenson, K.E. Knox, J. Nielson, A.L. Grant, D.L. Hancock, and J.Turek. 1995. Effects of antigenic challenge on growth and composition of segregated early-weaned pigs. Swine Health Prod. 3:228-234.

    23. Zabolotsky, D.A., L.F. Chen, J.A. Patterson, J.C. Forrest, H.M. Lin, and A.L. Grant. 1995. Supercritical carbon dioxide extraction of androstenone and skatole from pork fat. J. Food Sci. 60:1006-1008.

    24. Dodson, M.V., D.C. McFarland, A.L. Grant, M.E. Doumit, and S.G. Velleman. 1996. Extrinsic regulation of domestic animal-derived satellite cells. Dom. Anim. Endocrinology 13:107-126.

    25. Reecy, J.M., C.A. Bidwell, G.P. Briley, and A.L. Grant. 1996. Structure and regulation of the porcine skeletal a-actin-encoding gene. Gene 180:23-28.

    26. Gerrard, D.E., C.S. Okamura, M.A. Ranalletta, and A.L. Grant. 1998. Developmental expression and location of IGF-I and IGF-II mRNA and protein in skeletal muscle. J. Anim. Sci. 76:1004-1011.

    27. Fligger, J.M., P.V. Malven, M.E. Doumit, R.A. Merkel, and A.L. Grant. 1998. Increases in insulin-like growth factor binding protein-2 accompany decreases in proliferation and differentiation when porcine muscle satellite cells undergo multiple passages. J. Anim. Sci. 76:2086-2093.

    28. Reecy, J.M., C.A. Bidwell, O.M. Andrisani, D.E. Gerrard, and A.L. Grant. 1998. Multiple regions of the porcine alpha-skeletal actin gene modulate muscle-specific expression in cell culture and directly injected skeletal muscle. Anim. Biotech. 9:101-120.

    29. Taylor-Roth, J.L., P.V. Malven, D.E. Gerrard, S.E. Mills, and A.L. Grant. 1998. Independent effects of food intake and insulin status on insulin-like growth factor-I in young pigs. Comp. Biochem. Physiol. Pt. C 120:357-363.

    30. Holck, J.T., A.P. Schinckel, J.L. Coleman, V.M. Wilt, C. Christensen, E.L. Thacker, M.E. Spurlock, A.L. Grant, M.K. Senn, and B.J. Thacker. 1998. Influence of environment on growth and composition of commercial finisher pigs and an evaluation of potential biomarkers. Swine Health Prod. 6:141-149.

    31. Diekman, M.A., A.B. Scheidt, A.L. Grant, D.T. Kelly, A.L. Sutton, T.G. Martin, and T.R. Cline. 1998. Effect of vaccination on health, growth, and pubertal status of gilts exposed to moderate ammonia concentrations in all-in-all-out versus continuous-flow systems. Swine Health Prod. 7:55-61.

    32. Spurlock, M.E., M.A. Ranalletta, S.G. Cornelius, G.R. Frank, G.M. Willis, S. Ji, A.L. Grant, and C.A. Bidwell. 1998. Leptin expression in porcine adipose tissue is not increased by endotoxin but is reduced by growth hormone. J. Interferon Cytokine Res. 18:1051-1058.

    33. Ice, A.D., A.L. Grant, L.K. Clark, T.R. Cline, M.E. Einstein, T.G. Martin, and M.A. Diekman. 1999. Health and growth performance of barrows reared in all-in/all-out or continuous flow facilities with or without a chlortetracycline feed additive. Amer. J. Vet. Res. 60:603-608.

    34. Gerrard, D.E., C.S. Okamura, and A.L. Grant. 1999. Expression and location of IGF binding proteins-2, -4, and -5 in developing fetal tissues. J. Anim. Sci. 77:1431-1441.

    35. Blanton, J.R., A.L. Grant, D.C. McFarland, J.P. Robinson, and C.A. Bidwell. 1999. Isolation of two populations of myoblasts from porcine skeletal muscle. Muscle and Nerve 22:43-50.

    36. Grant, A.L. and D.E. Gerrard. 1998. Cellular and molecular approaches for altering muscle growth and development. Can. J. Anim. Sci. 78:493-502.

    37. Wynveen, E.J., B.C. Bowker, A.L. Grant, B.P. Demos, and D.E. Gerrard. 1999. Effects of muscle pH and chilling on development of PSE-like turkey breast meat. British Poul. Sci. 40:253-256.

    38. Bowker, B.C., E.J. Wynveen, A.L. Grant, and D.E. Gerrard. 1999. Effects of electrical stimulation on early postmortem muscle pH and temperature declines in pigs from different genetic lines and halothane genotypes. Meat Sci. 53:125-133.

    39. Li, Y., M.F. Seifert, D.M. Ney, M. Grahn, A.L. Grant, K.G.D. Allen, and B.A. Watkins. 1999. Dietary conjugated linoleic acids alter serum IGF-I and IGF binding protein concentrations and reduce bone formation in rats fed (n-6) or (n-3) fatty acids. J. Bone Min. Res. 14:1153-1162.

    40. Blanton, J.R., C.A. Bidwell, D.A. Sanders, C.M. Sharkey, D.C. McFarland, D.E. Gerrard, and A.L. Grant. 2000. Plasmid transfection and retroviral transduction of porcine muscle cells for cell-mediated gene transfer. J. Anim. Sci. 78:909-918.

    41. Everett, R.S.R., D.E. Gerrard, and A.L. Grant. 2000. Factors affecting production of luciferase and epitope-tagged IGF-I in porcine muscle following DNA injection. J. Endocrinol. 166:255-263.

    42. Reichel, C.L., A.L. Grant, R.S.R. Everett, C.A. Bidwell, and D.E. Gerrard. 2000. Epitope-tagged insulin-like growth factor-I expression in muscle. Dom. Anim. Endocrinol. 18:337-348.

    43. Depreux, F.F.S., C.S. Okamura, D.R Swartz, A.L Grant, A.M. Brandstetter and D.E. Gerrard. 2000. Quantification of myosin heavy chain isoform content in porcine muscle using an enzyme-linked immunosorbent assay. Meat Science 56:261-269.

    44. Bowker, B.C., A.L. Grant, J.C. Forrest, and D.E. Gerrard. 2000. Muscle biology and pork quality. Proc. Am. Soc. Anim. Sci.; available at: http://www.asas.org/symposia/2000proc.htm.

    45. Blanton, J.R., J.P. Robinson, C.A. Bidwell, D.E. Gerrard, and A.L. Grant. 2000. Rapid purification of transfected porcine muscle cells. Meth. Cell Sci. 22:217-223.

    46. Wynveen, E.J., B.C. Bowker, A.L. Grant, L. Henson, and D.E. Gerrard. 2001. Ability of early postmortem phosphate injection to inhibit PSE development. J. Food Sci. 66:886-891.

    47. Depreux, F.F.S., A.L. Grant, and D.E. Gerrard. 2002. Influence of halothane genotype and body weight on myosin heavy chain composition in pig muscle as related to meat quality. Livestock Prod. Sci. 73:265-273.

    48. Depreux, F.F.S., A.L. Grant, D.B. Anderson, and D.E. Gerrard. 2002. Paylean alters myosin heavy chain isoform content in pig muscle. J. Anim. Sci. 80:1888-1894.

    49. Eggert, J.M., F.F.S. Depreux, A.P. Schinckel, A.L. Grant, and D.E. Gerrard. 2002. Myosin heavy chain isoforms account for variation in pork quality. Meat Science 61:117-126.

    50. Hammelman, J.E., B.C. Bowker, A.L. Grant, J.C. Forrest, A.P. Schinckel, and D.E. Gerrard. 2003. Early postmortem electrical stimulation stimulates PSE pork development. Meat Sci. 63:69-77.

    51. Bowker, B.C., D.R. Swartz, A.L. Grant, and D.E. Gerrard. 2004. Method of isolation, rate of postmortem metabolism, and myosin heavy chain isoform composition influence ATPase activity of isolated porcine myofibrils. Meat Sci. 66(3) 743-752.

    52. Bowker, B.C., A.L. Grant, D.R. Swartz and D.E. Gerrard. 2004. Myosin heavy chain isoforms influence myofibrillar ATPase activity under simulated postmortem pH, calcium, and temperature conditions. Meat Sci. 67(1):139-147.

    53. Bowker, B.C., C. Botrel, D. R. Swartz, A. L. Grant, and D. E. Gerrard. 2004. Influence of myosin heavy chain isoform expression and postmortem metabolism on the ATPase activity of muscle fibers. Meat Sci. 68(4):587-594.

    54. Bowker, B.C., D. R. Swartz, A. L. Grant, and D. E. Gerrard. 2005. Myosin heavy chain isoform composition influences the susceptibility of actin-activated S1 ATPase and myofibrillar ATPase to pH inactivation. Meat Sci. 71(2):342-350.

    55. Freese, L.G., C. Rehfeldt, R. Fuerbass, G. Kuhn, C.S. Okamura, K. Ender, A.L. Grant, and D.E. Gerrard. 2005. Exogeneous somatotropin alters IGF axis in porcine endometrium and placenta. Dom. Anim. Endocrinol. 29:457-475.

    56. Copenhafer, T.L., B.T. Richert, A.P. Schinckel, A.L. Grant, and D.E. Gerrard. 2006. Augmented postmortem glycolysis does not occur early postmortem in AMPK gamma 3-mutated porcine muscle of halothane positive pigs. Meat Sci. 73(4):590-599.

    57. Selby, T.L., A. Berzins, D.E. Gerrard, C.M. Corvalan, A.L. Grant, and R.H. Linton. 2006. Microbial heat resistance of Listeria monocytogenes and the impact on ready-to-eat meat quality after post-package pasteurization. Meat Sci. 74(3):425-434.

    58. Guo, Q., B.T. Richert, J.R. Burgess, D.M. Webel, D.E. Orr, M. Blair, A.L. Grant, and D.E. Gerrard. 2006. Effect of dietary vitamin E supplementation and feeding period on pork quality. J. Anim. Sci. 84:3071-3078.

    59. Guo, Q., B.T. Richert, J.R. Burgess, D.M. Webel, D.E. Orr, M. Blair, G.E. Fitzner, D.D. Hall, A.L. Grant, and D.E. Gerrard. 2006. Effects of dietary vitamin E and fat supplementation on pork quality. J. Anim. Sci. 84:3089-3099.

    60. Eggert, J.M., A.L. Grant, and A.P. Schinckel. 2007. Factors affecting fat distribution in pork carcasses. Prof. Anim. Sci. 23:42-53.

  2. Research Abstracts:

    3.

    1. Nocek, J.E., A.L. Grant, and J.E. English. 1984. Characterization of in situ fiber digestion of forages stored at different dry matters. J. Dairy Sci. 67(Suppl. 1):248.

    2. Grant, A.L., J.W. Thomas, K.J. King, and C.A. Rotz. 1985. Propionic acid as a preservative in high moisture alfalfa hay. J. Dairy Sci. 68(Suppl. 1):153.

    3. King, K.J., J.W. Thomas, and A.L. Grant. 1985. Fermentation characteristics of inoculated haylage and corn silage. J. Dairy Sci. 68(Suppl. 1):151.

    4. Nocek, J.E. and A.L. Grant. 1985. Influence of bacterial nitrogen contamination on in situ nitrogen digestion of forages stored at different dry matters. Proc. Rumen Function Conf. 18:27.

    5. O'Neil, K.A., J.W. Thomas, A.L. Grant, and J.S. Liesman. 1986. Effect of microbial inocula and sucrose on fermentation of alfalfa haylage. J. Anim. Sci. 63(Suppl. 1):286.

    6. Grant, A.L., J.W. Thomas, R.S. Emery, and J.S. Liesman. 1986. Comparative efficacy of three forms of magnesium oxide for early lactation. J. Anim. Sci. 63(Suppl. 1):405.

    7. Grant, A.L., J.W. Thomas, R.S. Emery, K.J. King, and J.S. Liesman. 1987. Small intestinal parameters in piglets fed an all-milk protein milk replacer or a special soy protein concentrate replacer supplemented with amines. J. Anim. Sci. 65(Suppl. 1):293.

    8. Grant, A.L., R.E. Holland, J.W. Thomas, R.S. Emery, K.J. King, and J.S. Liesman. 1987. The use of dietary amines to improve milk replacers containing soybean protein. J. Dairy Sci. 70(Suppl. 1):144.

    9. Fish, S.F., A.L. Grant, and R.A. Patton. 1988. Effect of ammoniation on the viability of lactobacilli in corn silage. J. Anim. Sci. 66(Suppl. 1):167.

    10. King, K.J., J.T. Huber, M.S. Sadik, W.G. Bergen, A.L. Grant, and V.L. King. 1988. Influence of protein sources fed to lactating cows on the amino acids available for digestion and metabolism. J. Dairy Sci. 71(Suppl. 1):159.

    11. King, K.J., W.G. Bergen, N.K. Ames, A. L. Grant, and B.D. Grieve. 1988. Lysine adequacy of the lactating dairy cow. J. Anim. Sci. 66(Suppl. 1):484.

    12. Skjaerlund, D.M., W.G. Helferich, A.L. Grant, W.G. Bergen, and R.A. Merkel. 1989. Effect of ractopamine treatment and subsequent withdrawal on porcine skeletal muscle alpha actin mRNA abundance. Proc. Rec. Meat Conf. 42:54.

    13. Skjaerlund, D.M., W.G. Helferich, A.L. Grant, W.G. Bergen, and R.A. Merkel. 1989. Developmental changes in porcine skeletal muscle alpha actin mRNA abundance in pig heart and pig skeletal muscle. J. Anim. Sci. 67(Suppl. 1):188.

    14. Skjaerlund, D.M., W.G. Helferich, A.L. Grant, W.G. Bergen, and R.A. Merkel. 1989. Characterization of a full length human skeletal muscle alpha actin cDNA for use in meat animal species. J. Anim. Sci. 67(Suppl. 1):188.

    15. Grant, A.L., R.A. Merkel, and W.G. Bergen. 1989. Effects of beta adrenergic agonists and antagonists on proliferation of muscle satellite cells isolated from neonatal pigs. J. Anim. Sci. 67(Suppl. 1):192.

    16. Grant, A.L., W.G. Helferich, R.A. Merkel and W.G. Bergen. 1989. Proliferation of chick breast muscle satellite cells cultured with beta adrenergic agonists. J. Anim. Sci. 67(Suppl. 2):74.

    17. Chang, C.H., W.G. Helferich, A.L. Grant, A. Veit, R.A. Merkel, and W.G. Bergen. 1989. Specificity of the goose and rat fatty acid synthetase cDNA to RNA isolated from porcine adipose tissue. J. Anim. Sci. 67(Suppl. 1):208.

    18. Anderson, P.T., W.G. Helferich, R.A. Merkel, A.L. Grant, and W.G. Bergen. 1990. The effect of beta adrenergic agonists on protein synthesis and degradation in L6 myoblasts. Fed. Amer. Soc. Exp. Biol. J. 4:A505.

    19. Chang, C.H., W.G. Helferich, A.L. Grant, R.A. Merkel, and W.G. Bergen. 1990. Transcription assay development with nuclei isolated from pig skeletal muscle. Fed. Amer. Soc. Exp. Biol. J. 4:A384.

    20. Grant, A.L., W.G. Helferich, R.A. Merkel, and W.G. Bergen. 1990. Relative abundance of IGF-I mRNA in liver of pigs fed ractopamine. Fed. Amer. Soc. Exp. Biol. J. 4:A378.

    21. Kramer, S.A., A.L. Grant, L.J. Lutchka, R.J. Burnett, H. Hassan, W.G. Bergen, and R.A. Merkel. 1990. Effects of recombinant porcine somatotropin (rpST) on lipid metabolism in finishing pigs. J. Anim. Sci. 68(Suppl. 1):277.

    22. Grant, A.L., W.G. Helferich, S.A. Kramer, R.A. Merkel, and W.G. Bergen. 1990. Effect of recombinant porcine somatotropin on relative abundance of IGF-I mRNA in liver and skeletal muscle of pigs. J. Anim. Sci. 68(Suppl. 1):288.

    23. Gerrard, D.E., K.H. Thrasher, A.L. Grant, R.P. Lemenager, and M.D. Judge. 1991. Serum-induced myoblast proliferation and gene expression during development of double muscled and normal cattle. J. Anim. Sci. 69(Suppl. 1):317.

    24. Gerrard, D.E., K.H. Thrasher, A.L. Grant, R.P. Lemenager, and M.D. Judge. 1991. Serum-induced myoblast proliferation and gene expression during development of double muscled and normal cattle. Proc. Rec. Meat Conf. 44:203-204.

    25. Thrasher, K.H., D.E. Gerrard, S.Q. Ji, S.E. Mills, and A.L. Grant. 1991. The effect of the b-adrenergic agonist isoproterenol on insulin binding in cultured muscled cells. J. Anim. Sci. 69(Suppl. 1):317.

    26. Liu, C.Y., A.L. Grant, K.H. Kim, and S.E. Mills. 1991. Effects of recombinant porcine somatotropin on acetyl-CoA carboxylase enzyme activity and gene expression in adipose tissue of pigs. J. Anim. Sci. 69(Suppl. 1):309.

    27. Beermann, D.H., J.P. McMurtry, W.G. Helferich, A.L. Grant, T.M. Byrem, B.J. Krick, and R.D. Boyd. 1992. Effects of dietary protein intake and exogenous porcine somatotropin on skeletal muscle growth, plasma IGF-I concentrations and skeletal muscle gene expression in 20 to 60 kg pigs. Fed. Amer. Soc. Exp. Bio. J. 6:A1938.

    28. Liu, C.Y., A.L. Grant, and S.E. Mills. 1992. Effects of recombinant porcine somatotropin on glucose transporter (Glut 1 and Glut 4) mRNA in pig adipose and skeletal muscle. J. Anim. Sci. 70(Suppl. 1):208.

    29. Liu, C.Y., A.L. Grant, S. Ji, D.L. Hancock, D.B. Anderson, K.H. Kim, and S.E. Mills. 1992. Differential regulation of acetyl-CoA carboxylase enzyme activity and gene expression in outer and middle backfat layers from pigs fed ractopamine. J. Anim. Sci. 70(Suppl. 1):208.

    30. Demos, B.P., J.C. Forrest, A.L. Grant, and M.D. Judge. 1992. Simulating sensory and physical characteristics of beef in low-fat, low-salt restructured steaks. J. Anim. Sci. 70(Suppl. 1):226.

    31. Demos, B.P., J.C. Forrest, A.L. Grant, and M.D. Judge. 1992. Simulating sensory and physical properties of beef in low-fat, low-salt restructured steaks. Proc. Rec. Meat Conf. 45:206.

    32. Gerrard, D.E., A.L. Grant, and M.D. Judge. 1992. Serum-induced myoblast proliferation and gene expression in double muscled and normal cattle. Proc. Int. Congr. Meat Sci. Tech. 38:73.

    33. Lin, R.S., J.C. Forrest, M.D. Judge, R.P. Lemenager, and A.L. Grant. 1992. Application of electromagnetic scanning for prediction of beef carcass composition. Proc. Int. Congr. Meat Sci. Tech. 38:927.

    34. Taylor, J.L., J.W. Leininger, A.P. Schinckel, and A.L. Grant. 1993. Muscle protein metabolism in two genotypes of swine with different lean growth rates. J. Anim. Sci. 71(Suppl. 1):128.

    35. Zabolotsky, D.A., J.C. Forrest, M.D. Judge, L.F. Chen, H.M. Lin and A.L. Grant. 1993. Boar taint measurement using supercritical fluid extraction. J. Anim. Sci. 71(Suppl. 1):155.

    36. Diekman, M.A., A.L. Grant, D.L. Kelley, A.E. Pusateri, J.R. Wagner, A.B. Scheidt, A.L. Sutton, and T.R. Cline. 1994. Reproductive and lean growth performance of gilts reared in all-in/all-out facilities: Effect of vaccination against Mycoplasmal hyopneumoniae and exposure to ammonia. J. Anim. Sci. 72(Suppl. 2):42.

    37. Briley, G.P., J.M. Reecy, A.L. Grant, and C.A. Bidwell. 1994. Cloning and expression of the porcine myogenin gene. J. Animal Sci. 72(Suppl. 1):248.

    38. Gerrard, D.E., A.L. Grant, D.B. Anderson, R.L. Lemenager, L.A. Horstman, and M.D. Judge. 1994. In vivo analysis of serum-borne growth factors in developing co-twinned fetuses. J. Animal Sci. 72(Suppl.1):70.

    39. Gerrard, D.E., A.L. Grant, C.S. Okamura, T.V. Moran, and M.E. Spurlock. 1994. Developmental expression and location of IGF-I and IGF-II mRNA in porcine skeletal muscle. J. Animal Sci. 72(Suppl. 1):70.

    40. Fligger, J.M., A.L. Grant, C.A. Bidwell, M.E. Doumit, and R.A. Merkel. 1994. Secretion of insulin-like growth factor binding proteins (IGF-BP) by senescent and non-senescent porcine satellite cells. J. Animal Sci. 72(Suppl. 1):211.

    41. Taylor, J.L., A.E. Pusateri, T.M. Jones, and A.L. Grant. 1994. Regulation of circulating concentrations of insulin-like growth factor-I (IGF-I) by feed intake in streptozotocin-diabetic pigs. J. Animal Sci. 72 (Suppl. 1):163.

    42. Taylor J.L., J.M. Fligger, P.V. Malven, and A.L. Grant. 1994. Interaction of food intake and diabetes on insulin-like growth factor-I (IGF-I) in pigs. Abstracts 76th Ann. Mtg. The Endocrine Society, p. 550.

    43. Reecy, J.M., C.A. Bidwell, and A.L. Grant. 1995. Marker gene expression by the cloned porcine skeletal a-actin promoter in vitro and in vivo. Proc. Exper. Biol. Mtg. FASEB J. 9:A827.

    44. Taylor, J.L., A.L. Grant, P.V. Malven, and D.E. Gerrard. 1995. Independent effects of restricted feed intake and streptozotocin diabetes on the growth hormone/IGF-I axis in pigs. J. Anim. Sci. 73(Suppl. 1):67.

    45. Reecy, J.M., C.A. Bidwell, and A.L. Grant. 1995. Identification of enhancer-like regions in the porcine skeletal a-actin gene. J. Anim. Sci. 73(Suppl. 1):144.

    46. Gerrard, D.E., C.S. Okamura, T.V. Moran, and A.L. Grant. 1995. Developmental expression and location of IGF binding proteins and mRNA in porcine skeletal muscle. J. Anim. Sci. 73(Suppl. 1):64.

    47. Stadelman, W.J., H. Schmieder, A.L. Grant, R.F. Ghiselli, R.L. Adams, and K.W. McMillin. 1995. A buyer's guide for ostrich meat. Poul. Sci. 74 (Suppl. 1):120.

    48. Schinckel, A.P., A.L. Grant, L.K. Clark, and J.J. Turek. 1996. Health status-environmental effects on swine growth. J. Anim. Sci. 74(Suppl. 1):35.

    49. Reecy, J.M., C.A. Bidwell, and A.L. Grant. 1996. Different DNA elements control porcine alpha-actin transcription in cultured myotubes and skeletal muscle. J. Anim. Sci. 74(Suppl. 1):139.

    50. Berg, E.P., A.L. Grant, J.C. Forrest, and D.E. Gerrard. 1996. Electrophoretic separation of porcine myosin heavy chain isoforms. J. Anim. Sci. 74(Suppl. 1):139.

    51. Reecy, J.M., C.A. Bidwell, J.W. Leininger, D.E. Gerrard, and A.L. Grant. 1996. Intramuscular injection of DNA to identify DNA elements that control porcine alpha-skeletal actin transcription in skeletal muscle. Proc. Rec. Meat Conf. 49:188.

    52. Holck, J.T., A.P. Schinckel, J.L. Coleman, V.M. Vilt, E.L. Thacker, M. Spurlock, A.L. Grant, P.V. Malven, M.K. Senn, B.J. Thacker. 1997. Environmental effects on the growth of finisher pigs. J. Anim. Sci. 75(Suppl. 1):246.

    53. Ice, A.D., A.L. Grant, L.K. Clark, T.R. Cline, T.G. Martin, and M.A. Diekman. 1997. Health and lean growth performance of barrows reared in all-in/all-out or continuous flow facilities with or without antibiotic. J. Anim. Sci. 75(Suppl. 1):241.

    54. McComb, M.A., J.W. Frank, A.P. Schinckel, B.T. Richert, P.V. Malven, and A.L. Grant. 1997. Interactive effects of rearing environment, pig genotype and antibiotic therapy on growth, serum IGF-I and acute phase proteins. J. Anim. Sci. 75(Suppl. 1):178.

    55. Frank, J.W., B.T. Richert, A.P. Schinckel, B.A. Belstra, and A.L. Grant. 1997. Environmental effects on genetic potential for lean gain. J. Anim. Sci. 75(Suppl. 1):38.

    56. Spurlock, M.E., M.A. McComb, S.G. Cornelius, G.R. Frank, G,M. Willis, and A.L. Grant. 1997. Effect of growth hormone and immune challenge on serum concentrations of insulin-like growth factor-I and other components and adipose adipsin expression in pigs. J. Anim. Sci. 75(Suppl. 1):85.

    57. Eggert, J.M., A.L. Grant, E.B. Sheiss, and A.P. Schinckel. 1997. Effects of genotype, sex, slaughter weight and dietary fat on pork quality. J. Anim. Sci. 75(Suppl. 1):178.

    58. Eggert, J.M., A.P. Schinckel, E.B. Sheiss, and A.L. Grant. 1997. Effects of genotype, sex, slaughter weight and dietary fat on porcine carcass fat distribution. J. Anim. Sci. 75(Suppl. 1):178.

    59. Frank, J.W., B.T. Richert, A.P. Schinckel, B.A. Belstra, M.Ellis, and A.L. Grant. 1997. Effects of genotype and sex on pork quality. J. Anim. Sci. 75(Suppl. 1):246.

    60. Jacobi, S.K., D.E. Gerrard, C.A. Bidwell, and A.L. Grant. 1997. Direct DNA injection into skeletal muscle of pigs for delivery of recombinant protein. J. Anim. Sci. 75(Suppl. 1):165.

    61. Blanton, J.R., A.L. Grant, D.C. McFarland, J.P. Robinson, and C.A. Bidwell. 1997. Isolation of porcine myoblasts by flow cytometry. J. Anim. Sci. 75(Suppl. 1):165.

    62. Blanton, J.R., C.A. Bidwell, D.C. McFarland, D.A. Sanders, C.M. Sharkey, and A.L. Grant. 1998. Plasmid transfection and retroviral transduction of pig muscle cells. J. Anim. Sci. 76(Suppl 1):115.

    63. Depreux, F.F.S., A.L. Grant, J.C. Forrest, and D.E. Gerrard. 1998. Effect of halothane gene status on myosin heavy chain content and meat quality attributes. J. Anim. Sci. 76(Suppl 1):151.

    64. Reichel, C.L., A.L. Grant, C.A. Bidwell, and D.E. Gerrard. 1998. Development and biological activity of epitope-tagged porcine IGF-I. J. Anim. Sci. 76(Suppl 1):128.

    65. Everett, R.S.R., C.L. Reichel, C.A. Bidwell, D.E. Gerrard, and A.L. Grant. 1998. Direct plasmid DNA injection into longissimus muscle of pigs for recombinant protein production. J. Anim. Sci. 76(Suppl. 2):41.

    66. Eggert, J.M., S.E. Mills, A.P. Schinckel, J.C. Forrest, A.L. Grant, B.A. Watkins, and E.J. Farrand. 1998. Effects of genotype and dietary fat on pork quality and carcass composition. J. Anim. Sci. 76(Suppl. 2):44.

    67. Li, Y., M.F. Seifert, L. Kanach, A.L. Grant, and B.A. Watkins. 1998. Dietary CLA and N-3 PUFA altered serum insulin-like growth factor binding protein (IGFBP), liver IGF-1 mRNA, and bone histomorphometry in rats. FASEB Journal 12:A534.

    68. Blanton, J.R., A.L. Grant, J.P. Robinson, K.E. Ragheb, D.C. McFarland, and C.A. Bidwell. 1998. Isolation of porcine myoblasts by flow cytometry accompanied by molecular tagging with green fluorescent protein. Cytometry 32(Suppl. 9):68.

    69. Eggert, J.M., F.F.S. Depreux, N. Ratliff, A.P. Schinckel, A.L. Grant, E.B. Sheiss, E.P. Berg, and D.E. Gerrard. 1999. Differences in the effects of the halothane gene and muscle fiber type composition on pork composition and quality. J. Anim. Sci. 77(Suppl. 1):169.

    70. Everett, R.S.R., D.E. Gerrard, and A.L. Grant. 1999. Intramuscular injection of DNA encoding IGF-I increases IGF binding protein-2 expression in pigs. J. Anim. Sci. 77(Suppl. 1):160.

    71. Bidwell, C.A., A.L. Grant, C.M. Sharkey, C. Reichel, D.A. Sanders, D.E. Gerrard, D.C. McFarland, J.P. Robinson, J.R. Blanton, R.S.R. Everett, and S. Jacobi. 1999. Horizontal gene transfer in pig skeletal muscle. Plant & Anim. Genome VII Conf., J. Agricultural Genomics (http://www.intl-pag.org/pag/7/abstracts/pag7575.html).

    72. Hammelman, J.E., B.C. Bowker, M.S. Spires, Q. Guo, J.C. Forrest, A.L. Grant, and D.E. Gerrard. 2000. Time of electrical stimulation on muscle pH, temperature, and meat quality in pork carcasses. Proc. Rec. Meat Conf. 53:121.

    73. Armstrong, J.K., P.V. Malven, A.L. Grant, and D.E. Gerrard. 2001. Muscle-derived insulin-like growth factor-I alters postnatal growth. J. Anim. Sci. 79(Suppl. 1):29.

    74. Spires, M.S., B.C. Bowker, A.L. Grant, and D.E. Gerrard. 2001. Enhanced rates of postmortem muscle glycolysis differ across porcine genotypes. J. Anim. Sci. 79(Suppl. 1):20.

    75. Bowker, B.C., D.R. Swartz, A.L. Grant, and D.E. Gerrard. 2001. Myofibrils isolated from red and white porcine muscles respond differently to pH. J. Anim. Sci. 79(Suppl. 1):18.

    76. Grant, A.L. and D.E. Gerrard. 2002. Muscle satellite cell research in meat animals. J.Anim. Sci. 80(Suppl. 2):53.

    77. Gerrard, D.E. and A.L. Grant. 2002. Importance of muscle fiber types in animal agriculture. J. Anim. Sci. 80(Suppl. 1):169.

    78. Eash, J.K., A. Olsen, A.L. Grant, D.E. Gerrard, and K.M. Hannon. 2003. Fibroblast growth factor receptor 1 mediates disuse atrophy in gastrocnemius and soleus muscles of mice. J. Anim. Sci. 81(Suppl. 2):57.

    79. Guo, Q., A.L. Grant, B.T. Richert,, A.P. Schinckel, and D.E. Gerrard. 2003. Ractopamine may improve meat quality by altering postmortem metabolism. J. Anim. Sci. 81(Suppl. 2):53.

    80. Dilger, A.C., A.L. Grant, M.E. Spurlock, and D.E. Gerrard. 2004. Integration of myostatin-null alleles in leptin db/db mice does not alter body composition. J. Anim. Sci. 82(Suppl. 1):136.

    81. Zeng, C., D.E. Gerrard, K.H. Hannon, and A.L. Grant. 2004. Recombinant hepatocyte growth factor (rHGF) over-expressed by C2C12 myoblasts is biologically active. J. Anim. Sci. 82(Suppl. 1):18.

    82. Grant, A.L. 2005. Production of IGF-I and its effects on muscle development. J. Anim. Sci. 83(Suppl. 2):86.

    83. Shi, H., A. Ricome, K. Hannon, A. Grant, and D. Gerrard. 2005. Beta-adrenergic agonist-induced skeletal muscle hypertrophy is fiber type-specific through differential involvement of the MAPK signaling pathway. J. Anim. Sci. 83(Suppl. 1):209.

    84. Eash, J.K., A.L. Grant, K.M. Hannon, and D.E. Gerrard. 2005. Fibroblast growth factor receptor 1 regulates protein metabolism in atrophic muscle. J. Anim. Sci. 83(Suppl. 1):385.

  3. Theses:

    4.

    1. Grant, A.L. 1987. Small Intestinal Variables in Young Piglets and Preruminant Calves Fed Milk Protein, Soybean Protein, or Soybean Protein Plus Putrescine or Ethylamine. M.S. Thesis, Michigan State Univ., E. Lansing.

    2. Grant, A.L. 1990. Utilization of Solution Hybridization to Examine Differential Effects of Growth Hormone and Ractopamine on the Relative Abundance of IGF-I mRNA in Liver and Skeletal Muscle of Pigs. Ph.D. Thesis, Michigan State Univ., E. Lansing.

  4. Textbooks and Book Chapters:

    5.

    1. Grant, A.L. and W.G. Helferich. 1991. Chapter 1: An overview of growth. pp. 1-16. In: Advances in Meat Research, Vol. 7 - Growth Regulation in Farm Animals. A.M. Pearson and T.R.Dutson (Eds.). Elsevier Applied Press, London, 1991.

    2. Grant, A.L. and D.E. Gerrard. 1998. Molecular and cellular aspects of muscle growth. pp. 58-69. In: Proc. Symp. on Animal Growth: Basic Aspects, Theory and Practice for the Future. J.W. Blum, T. Elsasser, and P. Guilloteau (Eds.). ISBN number 3-9521067-0-4.

    3. Gerrard, D.E. and A.L. Grant. 2003. Principles of Animal Growth and Development. 264 pages; Kendall/Hunt Publishing Co., IA; ISBN 0-7872-9147-1. Revised printing, 2006; 284 pages; ISBN: 978-0-7575-2986-3.

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